Dr Anna Wong, director of AVA's import and export regulation department, said it has a multi-pronged approach to tackling the problem.
This includes monitoring animal retailers and online platforms, as well as keeping an eye out on Singapore's checkpoints.
Singapore law firm Tan Rajah & Cheah has been appointed to recover assets seized by the Singapore authorities following investigations into the 1Malaysia Development Berhad (1MDB) scandal.
Mr Imran said he was unable to discuss the matter when asked by The Straits Times what and how much assets the Malaysian government is seeking to recover, and what legal action has been taken to date.
The Bernama report also said Malaysia's Attorney-General Tommy Thomas met his Singapore counterpart Lucien Wong recently to facilitate the return of the 1MDB assets.
When asked, an Attorney-General's Chambers spokesman said: "Assets seized by the Singapore authorities will be dealt with in accordance with the law.
In May, AVA also seized a tortoise and a skink from a seller, who had listed the reptiles for sale online.
Like with the ball python, AVA said it was alerted to the online advertisement by a member of the public.